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Frequency of cometylation of the promoter regions of BRCA1 and BRCA2 genes in the study groups
| Combined hypermethylation | Control, blood samples ( 62) | BC, blood samples ( 74) | BC, tumour samples ( 74) |
|---|---|---|---|
| BRCA1 UU BRCA2 UU | 57 (91.9%) | 55 (74.3%) | 31 (41.9%) |
| BRCA1 MU BRCA2 UU | 2 (3.2%) | 7 (9.5%) | 12 (16.2%) |
| BRCA1 UU BRCA2 MU | 3 (4.8%) | 10 (13.5%) | 17 (23.0%) |
| BRCA1 MU BRCA2 MU | 0 (0.0%) | 2 (2.7%) | 14 (18.9%) |
M – methylated; U – unmethylated.
