Table 5.

Summary of studies reporting time-to-event feeding support outcomes (n = 3)

Author year	Data source, territory, population	N	Age	Outcomes
Choi 2020 [51]	Retrospective chart reviews between January 2012 and March 2017 in a tertiary hospital Korea	11	Children	Median age months (IQR):
	Type 1 SMA			•Patients began tube feeding: 6 (3–7)
				•Discontinuation of oral breaks/milk feeding: 6 (3–6.5)
				The main reasons for switching to tube feeding were poor oral intake, recurrent pneumonia, and aspiration
Kaneko 2017 [14]	Japanese individuals enrolled by questionnaire who completed the questionnaire	112	Adults and children	Median age at the start of tube feeding support (range), months:
	Types 1–3 SMA	•Type 1 : 47		•Type 1a SMA (n = 36): 4 (1–40)
		•Type 2 : 42		•Type 1b SMA (n = 2): 12.5 (12–13)
		•Type 3 : 23
Wadman 2021 [13]	Data from a single-center retrospective study in the UK and a prospective multicenter study in Italy	146	Children and adolescents	Median age at starting of feeding difficulties (range), years:
	Type 2 SMA			•Total cohort (n = 146): 6.5 (0–16.5)
				•UK (n = 72): 6.9 (0–17)
				•Italy (n = 74): 6.0 (2–10)
				Median age at starting nasogastric tube (range), years:
				•UK (n = 72): 4.1 (1–17)
				•Italy (n = 74): NA
				Median age at gastrostomy (range), years:
				•UK (n = 72): 7.3 (3–19)
				•Italy (n = 74): NA

Abbreviations: IQR = interquartile range; NA = not applicable; SMA = spinal muscular atrophy.