Figure 5.

Histological Findings in Cardiac Sarcoidosis

(A to C) Native explanted heart of a 35-year-old male showing marked biventricular dilatation and thinning of anterior/inferior ventricular walls and septum. Both macroscopic transverse and histologic sections show extensive epicardial-mid-wall replacement fibrosis in LV inferior wall and inferoseptum (scanned slides, Azan Mallory Trichrome). In D, transillumination highlights the ectasia of the right ventricular outflow with almost no myocardium. E shows a typical compact noncaseating granuloma with giant cells (hematoxylin-eosin, 400x). LV = left ventricle