Figure 2.

Wound healing and histopathological characteristics of A_2AR KO and EC-A_2AR KO mice after full-thickness wounding. (A) Experimental procedure. (B) Photographs of representative wounds of mice at 0, 3 and 9 days postwounding. (C) Wound healing time for each experimental and control group (n = 7 for each group), **p < 0.01. (D) Time course of wound closure for each experimental and control group (n = 9 for each group). **p <0.01, compared with the appropriate controls; ^##p <0.01, compared with the previous adjacent time point. (E) Histopathological observation of wound healing at 6 and 9 days postwounding. Short scale bar, 200 µm; long scale bar, 50 µm. (F) Quantitative analysis of granulation tissue thickness at 6 and 9 days postwounding. **p < 0.01 (n = 5); NS, not significant. (G) Quantitative analysis of the crawling distance at 6 and 9 days postwounding; **p < 0.01 (n = 5); NS, not significant.