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. 2024 Aug 19;20(11):4438–4457. doi: 10.7150/ijbs.98362

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Sc/sn-transcriptome analysis illustrates differentially expressed genes in diverse liver cells. (A & B) Differentially expressed genes of hepatocytes, cholangiocytes, endothelial cells, hepatic stellate cells, B, T, NK, DCs, macrophages, monocytes and neutrophils (Sham + DR vs. Sham and SG vs. Sham) were illustrated in volcano plots. (C) Transcriptomic influences of hepatocytes, cholangiocytes, endothelial cells, hepatic stellate cells, B, T, NK, DCs, macrophages, monocytes and neutrophils in the liver were assessed with DEG numbers and cell proportion of total cells Abbreviations: Sham: sham surgery; DR: dietary restriction; SG: sleeve gastrectomy; DC: dendritic cells; NK: natural killers; B: B lymphocytes; T: T lymphocytes; Neu: neutrophils; Mac: macrophages; Mono: monocytes; Endo: endothelial cells; HSC: hepatic stellate cells; Chol: cholangiocytes; HepaC: hepatocytes; DEG: differentially expressed gene. The one-way ANOVA test followed by Tukey's multiple comparisons was performed. 'Adjust p < 0.05' represents statistical significance.