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. 2024 Aug 19;20(11):4438–4457. doi: 10.7150/ijbs.98362

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Sc/sn-transcriptome analysis illustrates up-regulated enriched pathways and cellular interactions in diverse liver cells. Significantly up-regulated (A) KEGG signaling pathways and (B) cellular interactions (numbers and strength) in hepatocytes, cholangiocytes, endothelial cells, hepatic stellate cells, B, T, NK, DCs, macrophages, monocytes and neutrophils were illustrated (Sham + DR vs. Sham and SG vs. Sham). Abbreviations: Sham: sham surgery; DR: dietary restriction; SG: sleeve gastrectomy; HepaC: hepatocytes; Chol: cholangiocytes; HSC: hepatic stellate cells; Endo: endothelial cells; Mono: monocytes; Mac: macrophages; DC: dendritic cells; Neu: neutrophils; NK: natural killer cells; B: B lymphocytes; T: T lymphocytes; KEGG: Kyoto encyclopedia of genes and genomes. The Fisher's exact test and the one-way ANOVA test followed by Tukey's multiple comparisons were performed. 'Adjust p<0.05' represents statistical significance.