Figure 8.

Sleeve gastrectomy induces phenotypic alterations in myeloid cells. (A) The expression of phenotype-associated markers in myeloid cell clusters was illustrated based on sc/sn RNA-seq data (SG vs. Sham). (B) Myeloid cells were characterized into phenotypic subtypes (SAM, LAM, non-/classical monocytes, KC, cDC1/2, mature/naïve neutrophils and other macrophages) with annotations. (C) The proportion of myeloid cell subtypes in Sham, Sham + DR and SG groups were illustrated. Abbreviations: Sham: sham surgery; DR: dietary restriction; SG: sleeve gastrectomy; sc/sn: single-cell/single-nuclei; Mono: monocytes; Mac: macrophages; (c)DC: (conventional) dendritic cells; Neu: neutrophils; SAM: scar-associated macrophage; LAM: lipid-associated macrophage; LCM: liver capsular macrophage; KC: Kupffer cell. The unpaired t-test and Fisher's exact test were performed. '*' represents 'p < 0.05' and statistical significance.