Table 3.

The therapeutic potential of exosomal ncRNAs.

ncRNAs	Carrier	Target	Model	Role	Reference
let-7a	Modified exosomes	EGFR-expressing breast cancer	In vivo and in vitro	Inhibited tumor growth	[195]
miR-497	Hybrid nanoparticles of liposomes and exosomes	Ovarian cancer	In vivo and in vitro	Led to tumor cell death and overcame drug resistance	[196]
anti-miR-21	Anti-exosome antibody–oligonucleotide complexes	Exosome	In vitro	Inhibited exosomal miR-21 to prohibit cancer cell growth	[199]
lncRNA MEG3	Modified exosomes	Osteosarcoma	In vivo and in vitro	Inhibited proliferation, migration and promoted apoptosis by regulating miR-185-5p	[197]
ciRS-122	Exosome	Colorectal cancer	In vivo and in vitro	Suppressed glycolysis and reversed resistance to oxaliplatin by regulating the ciRS-122-miR-122-PKM2 pathway	[198]