Table 2.
Two Genes With Suggestive Smoking-Associated SNPs in Northern New England and Ohio ALS Cohort
| CHR | Gene | Cytogenetic band | SNP ID | SNP positiona | Allelesb | MAFc | Odds ratio | Pd |
| 12 | GFD3 | 12p13.31 | rs3815479 | 12:7843373 | C/T | 0.49 | 0.53 | 4.23E-6 |
| 18 | MYO5B | 18q21.1 | rs201995562 | 18:47698658 | C/A | 0.33 | 2.19 | 3.13E-7 |
a
Positions are encoded in GRCh37/hg19.
b
Major allele/minor allele (effect allele).
c
Minor allele frequency (MAF).
d
p- Values of SNP-smoking interaction were calculated from logistic regression adjusting for sex, age at symptom onset, smoking main effect, and the first 10 principal components.