Table 3.
Eight Gene Expressions Identified by TWAS to be Suggestively Associated With ALS Risk With FDR <0.3
| Tissue | Gene | CHR | Cytogenetic band | Odds ratio | p Value | FDRa |
| Brain caudate | CEP43 b | 6 | 6q27 | 0.68 | 8.10E-6 | 0.03 |
| Brain caudate | ZNF235 | 19 | 19q13.31 | 0.71 | 6.76E-5 | 0.14 |
| Brain hippocampus | RPL7P18 | 5 | 5q15 | 0.71 | 5.05E-5 | 0.14 |
| Brain hippocampus | ANO5 | 11 | 11p14.3 | 0.72 | 1.35E-4 | 0.19 |
| Brain hippocampus | RP11-381K20.5 | 5 | 5q31.2 | 1.38 | 2.23E-4 | 0.21 |
| Brain substantia | ZBTB14 | 18 | 18p11.31 | 0.71 | 9.72E-5 | 0.20 |
| Whole blood | STIL | 1 | 1p33 | 0.64 | 3.36E-5 | 0.21 |
| Skeletal muscle | ZNF235 | 19 | 19q13.31 | 0.70 | 3.84E-5 | 0.29 |
a
FDR values were calculated in each tissue separately.
b
The CEP43 gene is also known as FGFR1OP.