Mathur 1981.
Methods | Allocation: randomly assigned, cross‐over design (after 6months). Blinding: double, given by hospital pharmacist in individual bottles. Duration: 16 months. | |
Participants | Diagnosis: schizophrenia. N=24. Age: mean 55 yrs. Sex: unknown. History: in hospital mean 27 yrs, stable on chlorpromazine >6 months. Setting: hostel. | |
Interventions | 1. Chlorpromazine cessation: placebo. N=12. 2. Chlorpromazine continuation: (dose not reported). N=12. | |
Outcomes | Relapse.
Leave the study early. Unable to use ‐ Death: 1 suicide (not reported by group). Behaviour: 1 person threatening (not reported by group). Global state: deterioration (not reported by group). Urine tests for the presence of phenothiazine. no data. |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment (selection bias) | Unclear risk | B ‐ Unclear |