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. 2007 Jan 24;2007(1):CD006329. doi: 10.1002/14651858.CD006329

Mathur 1981.

Methods Allocation: randomly assigned, cross‐over design (after 6months).
 Blinding: double, given by hospital pharmacist in individual bottles. 
 Duration: 16 months.
Participants Diagnosis: schizophrenia.
 N=24.
 Age: mean 55 yrs.
 Sex: unknown.
 History: in hospital mean 27 yrs, stable on chlorpromazine >6 months.
 Setting: hostel.
Interventions 1. Chlorpromazine cessation: placebo. N=12.
 2. Chlorpromazine continuation: (dose not reported). N=12.
Outcomes Relapse.
 Leave the study early.
Unable to use ‐
 Death: 1 suicide (not reported by group).
 Behaviour: 1 person threatening (not reported by group).
 Global state: deterioration (not reported by group).
 Urine tests for the presence of phenothiazine. no data.
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) Unclear risk B ‐ Unclear