Figure 6.

Young adult serum improves arterial function in old arteries. Elastic modulus in old aortas following exposure to midlife/older (ML/O) vs. young adult serum (A). Pearson’s correlation between serum-induced differences in aortic elastic modulus and participants’ pulse wave velocity in all subjects (B), in the young adult subgroup (C), and in the ML/O adult subgroup (D). Endothelium-dependent dilation (EDD) in response to acetylcholine (ACh; E and F) and endothelium-independent dilation in response to sodium nitroprusside (SNP; G) in old arteries following perfusion from ML/O vs. young adult serum. Pearson’s correlation between serum-induced differences in peak EDD and participant’s flow-mediated dilation in all subjects (H), in the young adult subgroup (I), and in the ML/O adult subgroup (J); n = 9 or 10/group. Data represent means ± SE. Triangles, women; squares, men; circles, combined sexes; gold shapes, young adults; gray shapes, ML/O adults. *P < 0.05 young vs. ML/O adult serum exposure. Figure created with Photoshop.