Predicting sudden cardiac death from ventricular arrhythmias (SCDA) risk in patients with different arrhythmogenic heart diseases. Arrhythmias in the different models are shown on left for each heart condition. White arrows indicate the ventricular tachycardia (VT) reentrant circuit in each model. ACCF/AHA, American College of Cardiology Foundation/American Heart Association; CHAI, Computational Heart and AI risk predictor; CI, confidence interval; ESC, European Society of Cardiology; FDG, fluorodeoxyglucose; GZ, gray zone; LGE, late gadolinium enhancement; LVEF, left ventricular ejection fraction; NPV, negative predictive value; PPV, positive predictive value; VARP, virtual heart arrhythmia predictor. Modified with permission from Ref. 264, with permission from Nature Communications; Ref. 262, with permission from eLife; and Ref. 263, with permission from Scientific Advances.