The effects of eye closure do not depend on eccentricity tuning. A: event-triggered average for BOLD response to luminance task across cortical ROI and eye condition separated by voxels tuned to different portions of the visual field. With eyes open and eyes closed, the BOLD responses to high-contrast stimuli are uniform across eccentricities for all cortical ROIs. Foveal voxels were tuned to between 0.01 dva and 1.5 dva. Parafoveal voxels were tuned to between 1.5 dva and 4.0 dva. Peripheral voxels were tuned to between 4.0 dva and 17 dva. B: average BOLD activation during stimulus presentation across conditions (top = eyes closed; bottom = eyes open), separated by eccentricity preference. There are no significant pairwise comparisons when comparing eccentricity responses within each ROI. The y-axis is BOLD signal averaged across 4–16 s poststimulus onset. Error bars and error shading are 1 SEM. BOLD, blood oxygenation level-dependent; ROI, region-of-interest; V1, primary visual cortex; V2 and V3, extrastriate visual cortex.