Table 3.
Risk Factors for Abnormal Lab Results on Isotretinoin Therapy
| Parameter | BMI | Dose | Gender | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Normal (n=377) | Abnormal (n=138) | P-value | ˂30 (n=362) | ≥30 (n=153) | P-value | Male (n=120) | Female (n=395) | P-value | |
| Hemoglobin | |||||||||
| Normal | 363 (96.3) | 131 (94.9) | 0.489 | 349 (96.4) | 145 (94.7) | 0.391 | 120 (100) | 374 (94.7) | 0.006* |
| Abnormal | 14 (3.7) | 7 (5.1) | 13 (3.6) | 8 (5.3) | 0 (0) | 21 (5.3) | |||
| Platelets | |||||||||
| Normal | 369 (97.9) | 136 (98.6) | 0.624 | 357 (98.6) | 148 (96.7) | 0.156 | 118 (98.3) | 387 (98) | 0.803 |
| Abnormal | 8 (2.1) | 2 (1.4) | 5 (1.4) | 5 (3.3) | 2 (1.7) | 8 (2) | |||
| WBC | |||||||||
| Normal | 364 (96.6) | 133 (96.4) | 0.923 | 350 (96.7) | 147 (96.1) | 0.731 | 119 (99.2) | 378 (95.7) | 0.069 |
| Abnormal | 13 (3.4) | 5 (3.6) | 12 (3.3) | 6 (3.9) | 1 (0.8) | 17 (4.3) | |||
| Hct | |||||||||
| Normal | 367 (97.3) | 138 (100) | 0.069 | 354 (97.8) | 151 (98.7) | 0.497 | 120 (100) | 385 (97.5) | 0.127 |
| Abnormal | 10 (2.7) | 0 (0) | 8 (2.2) | 2 (1.3) | 0 (0) | 10 (2.5) | |||
| Neutrophils (Count) | |||||||||
| Normal | 373 (98.9) | 136 (98.6) | 0.716 | 360 (99.4) | 149 (97.4) | 0.04* | 119 (99.2) | 390 (98.7) | 0.699 |
| Abnormal | 4 (1.1) | 2 (1.4) | 2 (0.6) | 4 (2.6) | 1 (0.8) | 5 (1.3) | |||
| Neutrophils (%) | |||||||||
| Normal | 331 (87.8) | 115 (83.3) | 0.187 | 319 (88.1) | 127 (83) | 0.119 | 109 (90.8) | 337 (85.3) | 0.120 |
| Abnormal | 46 (12.2) | 23 (16.7) | 43 (11.9) | 26 (17) | 11 (9.2) | 58 (14.7) | |||
| Total Cholesterol | |||||||||
| Normal | 116 (30.8) | 46 (33.3) | 0.283 | 116 (32) | 46 (30.1) | 0.659 | 27 (22.5) | 135 (34.2) | 0.016* |
| Abnormal | 261 (69.2) | 92 (66.7) | 246 (68) | 107 (69.9) | 93 (77.5) | 260 (65.8) | |||
| AST | |||||||||
| Normal | 364 (96.6) | 135 (97.8) | 0.460 | 348 (96.1) | 151 (99) | 0.126 | 111 (92.5) | 388 (98.2) | 0.001* |
| Abnormal | 13 (3.4) | 3 (2.2) | 14 (3.9) | 2 (1) | 9 (7.5) | 7 (1.8) | |||
| ALT | |||||||||
| Normal | 343 (91) | 120 (87) | 0.179 | 330 (91.2) | 137 (89.5) | 0.564 | 90 (75) | 377 (95.4) | 0.000* |
| Abnormal | 34 (9) | 18 (13) | 32 (8.8) | 16 (10.5) | 30 (25) | 18 (4.6) | |||
| HDL | |||||||||
| Normal | 355 (94.2) | 120 (87) | 0.006* | 341 (94.2) | 134 (87.6) | 0.010* | 101 (84.2) | 374 (94.7) | 0.000* |
| Abnormal | 22 (5.8) | 18 (13) | 21 (5.8) | 19 (12.4) | 19 (15.8) | 21 (5.3) | |||
| LDL | |||||||||
| Normal | 296 (78.5) | 111 (80.4) | 0.635 | 282 (77.9) | 125 (81.7) | 0.333 | 96 (80) | 311 (78.7) | 0.765 |
| Abnormal | 81 (21.5) | 27 (19.6) | 80 (22.1) | 28 (18.3) | 24 (20) | 84 (21.3) | |||
| Triglycerides | |||||||||
| Normal | 360 (95.5) | 134 (97.1) | 0.413 | 352 (97.2) | 142 (92.8) | 0.020* | 110 (91.7) | 384 (97.2) | 0.007* |
| Abnormal | 17 (4.5) | 4 (2.9) | 10 (2.8) | 11 (7.2) | 10 (8.3) | 11 (2.8) | |||
Note: *Significant at significance level (α≤0.05).