Figure 5.

CD8α and CD8β cytoplasmic tails: palmitoylation and binding mode to Lck. (A) A sequence alignment of human CD8α and human CD8β cytoplasmic tails is shown with palmitoylated residues indicated with an asterisk. (B) NMR structure of the interaction between a fragment of the cytoplasmic tail from CD8α with a fragment from Lck (PDB ID 1Q69). The interaction is coordination by a Zn²⁺ ion and Cys residues on CD8α and Lck. Other residues participating in the interaction are also shown as sticks. CD8α is colored magenta, Lck is colored salmon, and Zn²⁺ is colored gray.