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Binding modes of mABs to CD8αα and CD8αβ. A summary of crystal structures of CD8 ectodomain/mAB complexes. From top left to bottom right: mouse CDαα/YTS 105.18 (PDB ID 2ARJ), mouse CD8αβ/YTS 156.7 (PDB ID 3B9K), human CD8αα/ZED8 (PDB ID 7UVF), and human CD8α/VHH5v2 (PDB ID 8EW6). mABs are colored blue/light blue, CD8α chains are colored magenta/light pink, and CD8β chains are colored yellow. The orientation of the magenta CD8α is maintained throughout for comparison.
