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. 2024 Aug 26;15:1412513. doi: 10.3389/fimmu.2024.1412513

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Copyright © 2024 Srinivasan, Zhu and McShan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential for different mABs to block or enhance CD8αα and CD8αβ interactions with classical and non-classical MHC-I molecules. (A) Overlay of mouse CDαα/YTS 105.18 (PDB ID 2ARJ) with mouse CD8αβ/H-2D^d (PDB ID 3DMM). In this binding mode, no steric hindrance of CD8/MHC is seen. (B) Overlay of mouse CDαα/YTS 105.18 (PDB ID 2ARJ) with mouse CD8αα/H-2K^b (PDB ID 1BQH). In this binding mode, steric hindrance of CD8/MHC is seen. (C) Overlay of mouse CD8αβ/YTS 156.7 (PDB ID 3B9K) with mouse CD8αβ/H-2D^d (PDB ID 3DMM). In this binding mode, steric hindrance of CD8/MHC is seen. (D) Overlay of human CD8αα/ZED8 (PDB ID 7UVF) with mouse CD8αβ/H-2D^d (PDB ID 3DMM). In this binding mode, no steric hindrance of CD8/MHC is seen. (E) Overlay of human CD8αα/ZED8 (PDB ID 7UVF) with mouse CD8αα/H-2K^b (PDB ID 1BQH). In this binding mode, no steric hindrance of CD8/MHC is seen. (F) Overlay of human CD8α/VHH5v2 (PDB ID 8EW6) with mouse CD8αβ/H-2D^d (PDB ID 3DMM). In this binding mode, no steric hindrance of CD8/MHC is seen. (G) Overlay of human CD8α/VHH5v2 (PDB ID 8EW6) with mouse CD8αα/H-2K^b (PDB ID 1BQH). In this binding mode, steric hindrance of CD8/MHC is seen. In all panels, the orientation of the magenta CD8α1 is maintained throughout for comparison. MHC-I heavy chains are colored green, β2m light chains colored cyan, antigens colored salmon, CD8α chains colored magenta/light pink, CD8β chains colored yellow, and mABs colored blue/light blue.