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Outline of enhancer hijacking and HYENA algorithm. (A) Mechanisms of gene activation by SVs. SVs can activate genes by recruiting distal active enhancers (top panel) and by removing TAD boundaries and forming de novo enhancer-promoter interactions (bottom panel). (B) HYENA workflow. Green and purple boxes denote input and output files, respectively. Orange boxes denote intermediate steps. Numbers in parentheses represent the default parameters of HYENA.
