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. 2024 Jul 25;52(16):e77. doi: 10.1093/nar/gkae646

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© The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — 3D genome structures in the TOB1-AS1 locus in pancreatic cancer cell lines. (A) TOB1-AS1 expression in pancreatic cancer cell lines in CCLE. The cell lines in red are selected for further studies. (B, C) 3D genomic interactions in four pancreatic cancer cell lines. Black arrows represent SVs with off-diagonal interactions. The locations of TOB1-AS1 are marked by blue lines. In Panc 10.05, the blue arrow points to the CNV breakpoint and the dashed blue triangle represents the neo-subdomain formed due to the foldback inversion. (D) The reference chromosome 17 and derived chromosomes in Panc 10.05. The chromosomes are not to scale. TOB1-AS1 is shown as small blue boxes in the chromosomes. (E) Open chromatin measured by ATAC-Seq in PATU-8988S and PATU-8988T at the TOB1-AS1 locus.