Table 2.

Summary of 5mCs, C-to-T mutations and transcriptional profiles in three representative chromosomal segments

				Vegetative growtha		Sexual developmentb
Representative chromosomal segment (RCS)	Chromosomal location in QM6a	Transcription profiles	Long (>500 bps) AT-rich DNA	5mCs	C-to-T mutations	5mCs	C-to-T mutations
RCS1-GTX	ChXI GTX-BGC ±10 000 bp	Genes upregulated during sexual development	0	rare	rare	dim2	dim2
RCS2-SOR	ChV usk1-SOR-BGC-cel61a ±10 000 bp	Genes downregulated during sexual development	0	rare	rare	dim2	dim2
RCS3-AT containing five QM6a-specific, gene-free, AT-rich sequences	ChV 298991–447710 ±100 000 bp	QM6a-specific, gene-free, AT-rich DNA	5	dim2	rare	dim2 rid1 dimX	dim2 rid1 dimX
		Non-AT-rich Genes up- or down-regulated during sexual development	0	dim2	rare	dim2 rid1 dimX	dim2 rid1 dimX

^aDim2 is responsible for 5mCs at RSC3-AT in wild-type and rid1Δ vegetative mycelia, whereas C-to-T mutations were hardly detected at RCS1-GTX, RCS2-SOR and RCS3-AT in vegetative mycelia.

^bOnly Dim2 is responsible for 5mCs at RCS1-GTX and RCS2-SOR in the wild-type and rid1Δ fruiting bodies, whereas Dim2, Rid1 and DimX act redundantly to mediate 5mCs and C-to-T mutations at RCS3-AT in the fruiting bodies.