Fig. 3.

Deletion of Cldn3 does not alter intestinal fluxes of Pi. ³²P fluxes in the jejunum and ileum of WT and Cldn3 KO mice were measured with the Ussing chamber technique. A, B Active and passive transports under baseline dietary conditions. C, D Active and passive transports upon high dietary Pi challenge. E, F Jejunal transport values upon imposing 70 mM and 2 mM apical-to-basolateral (AP to BL) and basolateral-to-apical (BL to AP) Pi gradients. N = 7–10 mice per group. A–F Two-way ANOVA followed by Tukey’s multiple comparisons test. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001