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. 2024 Sep 8;15:7853. doi: 10.1038/s41467-024-52149-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Schematic of surface plasmon resonance (SPR) experiments where IL3-Fc is captured on a protein A sensor chip and AAV analyte flows over the sensor. v.g.: viral genomes. b SPR confirms serotype-specific interaction of AAV9 with the human immunomodulatory cytokine IL3. c SPR confirms AAV9 binding with macaque but not marmoset or mouse IL3. d SPR confirms that the VR-IV and VR-VIII modified AAV9-X1.1 capsid binds to human but not mouse IL3. Panel (a) created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license.