Table 3.
Effectiveness over 5 years in patients enrolled in the registry by JIA category (as-observed analysis)
| Parameter | Visit |
|||||||
|---|---|---|---|---|---|---|---|---|
| Baseline | 3 months | 6 months | 12 months | 24 months | 36 months | 48 months | 60 months | |
| Overall patients | ||||||||
| n | 569 | 448 (78.7%) | 421 (73.9%) | 387 (68.0%) | 274 (48.2%) | 154 (27.1%) | 99 (17.4%) | 50 (8.8%) |
| PGA (cm) | 1.0 (0.0, 3.0) | 1.0 (0.0, 2.5) | 1.0 (0.0, 2.5) | 0.5 (0.0, 2.0) | 0.5 (0.0, 2.0) | 0.5 (0.0, 1.0) | 0.0 (0.0, 1.5) | 1.0 (0.0, 2.0) |
| cJADAS10 (parent) | n = 484 | n = 348 | n = 329 | n = 285 | n = 169 | n = 87 | n = 44 | n = 16 |
| 5.5 (2.0, 11.3) | 4.5 (1.0, 9.5) | 3.5 (1.0, 9.5) | 2.5 (0.5, 6.5) | 2.0 (0.5, 5.5) | 3.0 (0.5, 6.0) | 3.0 (1.0, 6.5) | 3.3 (1.5, 6.8) | |
| No. of active joints (0–71) | 1.0 (0.0, 3.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 1.0) |
| No. of joints with LOM | 1.0 (0.0, 4.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 4.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 2.0) |
| Categories of polyarticular disease courses in patients with JIA | ||||||||
| Polyarticular RF− JIA | ||||||||
| n | 289 | 235 | 222 | 206 | 152 | 86 | 54 | 34 |
| PGA (cm) | 1.5 (0.5, 3.5) | 1.0 (0.0, 2.5) | 1.0 (0.0, 3.0) | 0.5 (0.0, 2.0) | 0.5 (0.0, 1.8) | 0.5 (0.0, 1.0) | 0.5 (0.0, 1.5) | 1.0 (0.0, 2.0) |
| cJADAS10 (parent) | n = 247 | n = 186 | n = 178 | n = 149 | n = 95 | n = 46 | n = 24 | n = 10 |
| 6.0 (2.0, 13.0) | 5.0 (1.0, 10.5) | 4.0 (1.5, 10.5) | 3.0 (0.5, 6.5) | 2.5 (0.5, 5.5) | 3.3 (1.0, 6.5) | 3.8 (1.0, 6.5) | 4.8 (1.5, 9.0) | |
| No. of active joints (0–71) | 1.0 (0.0, 4.0) | 0.0 (0.0, 3.0) | 1.0 (0.0, 3.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 2.0) |
| No. of joints with LOM | 1.0 (0.0, 6.0) | 0.0 (0.0, 4.0) | 1.0 (0.0, 5.0) | 0.0 (0.0, 4.0) | 0.0 (0.0, 3.0) | 1.0 (0.0, 3.0) | 0.0 (0.0, 3.0) | 0.5 (0.0, 2.0) |
| Oligoarticular JIA | ||||||||
| n | 134 | 111 | 102 | 87 | 63 | 35 | 22 | 9 |
| PGA (cm) | 1.0 (0.0, 3.0) | 0.5 (0.0, 2.0) | 0.8 (0.0, 2.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 1.0) | 0.5 (0.0, 2.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 1.5) |
| cJADAS10 (parent) | n = 116 | n = 87 | n = 80 | n = 74 | n = 43 | n = 24 | n = 14 | n = 5 |
| 4.0 (1.0, 8.5) | 3.0 (0.5, 7.5) | 3.0 (0.5, 7.5) | 1.3 (0.0, 5.0) | 2.0 (0.0, 5.0) | 3.0 (0.1, 5.3) | 2.3 (0.0, 7.0) | 3.0 (2.5, 3.0) | |
| No. of active joints (0–71) | 0.0 (0.0, 2.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 1.0) |
| No. of joints with LOM | 0.0 (0.0, 2.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 1.0) |
| Polyarticular RF+ JIA | ||||||||
| n | 54 | 36 | 37 | 37 | 24 | 15 | 9 | 2 |
| PGA (cm) | 1.0 (0.0, 3.0) | 0.5 (0.0, 2.0) | 1.0 (0.0, 2.0) | 0.5 (0.0, 2.0) | 0.8 (0.0, 2.0) | 1.0 (0.0, 2.5) | 0.0 (0.0, 1.5) | 0.3 (0.0, 0.5) |
| cJADAS10 (parent) | n = 43 | n = 25 | n = 31 | n = 22 | n = 9 | n = 6 | n = 1 | n = 0 |
| 5.0 (1.0, 9.0) | 2.0 (0.5, 5.5) | 3.0 (0.5, 11.0) | 1.5 (0.5, 6.0) | 5.5 (1.0, 7.0) | 0.8 (0.0, 3.0) | 0.0 (0.0, 0.0) | – | |
| No. of active joints (0–71) | 0.0 (0.0, 3.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 3.5) | 1.0 (0.0, 5.0) | 0.0 (0.0, 1.0) | 0.5 (0.0, 1.0) |
| No. of joints with LOM | 0.0 (0.0, 2.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 3.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 3.5) | 0.0 (0.0, 6.0) | 0.0 (0.0, 2.0) | 15.0 (0.0, 30.0) |
| Enthesitis-related JIA | ||||||||
| n | 20 | 15 | 15 | 13 | 6 | 3 | 3 | 0 |
| PGA (cm) | 2.8 (1.0, 3.8) | 1.0 (0.5, 2.5) | 1.5 (0.0, 2.5) | 1.0 (0.0, 1.5) | 0.5 (0.0, 1.0) | 0.0 (0.0, 0.5) | 0.0 (0.0, 0.5) | – |
| cJADAS10 (parent) | n = 15 | n = 10 | n = 11 | n = 9 | n = 5 | n = 2 | n = 1 | n = 0 |
| 9.0 (5.0, 17.0) | 5.3 (3.0, 10.0) | 6.0 (3.0, 10.5) | 5.0 (1.0, 9.0) | 2.5 (1.5, 4.0) | 3.8 (3.5, 4.0) | 2.0 (2.0, 2.0) | – | |
| No. of active joints (0–71) | 1.5 (0.5, 3.5) | 1.0 (0.0, 2.0) | 0.0 (0.0, 3.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 0.0) | – |
| No. of joints with LOM | 1.0 (0.0, 4.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 3.0) | 0.0 (0.0, 4.0) | 0.0 (0.0, 6.0) | 0.0 (0.0, 5.0) | – |
| Psoriatic JIA | ||||||||
| n | 26 | 21 | 18 | 16 | 10 | 7 | 6 | 2 |
| PGA (cm) | 0.5 (0.0, 2.0) | 0.5 (0.0, 1.5) | 0.5 (0.0, 1.0) | 0.8 (0.0, 1.5) | 0.0 (0.0, 0.5) | 0.0 (0.0, 1.0) | 0.0 (0.0, 2.5) | 0.3 (0.0, 0.5) |
| cJADAS10 (parent) | n = 23 | n = 16 | n = 13 | n = 13 | n = 5 | n = 4 | n = 4 | n = 1 |
| 4.0 (2.0, 8.0) | 4.8 (2.3, 5.8) | 3.5 (1.5, 5.5) | 2.5 (1.0, 6.0) | 1.0 (1.0, 1.0) | 2.8 (2.0, 3.8) | 2.8 (1.8, 5.5) | 1.5 (1.5, 1.5) | |
| No. of active joints (0–71) | 0.0 (0.0, 1.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 1.5) | 0.0 (0.0, 0.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 0.0) |
| No. of joints with LOM | 0.0 (0.0, 2.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 1.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 0.0) | 0.5 (0.0, 1.0) | 0.5 (0.0, 1.0) |
| Systemic JIA | ||||||||
| n | 13 | 9 | 10 | 7 | 6 | 3 | 1 | 1 |
| PGA (cm) | 2.5 (1.0, 4.0) | 3.0 (2.0, 3.0) | 3.0 (1.5, 4.0) | 2.0 (2.0, 3.0) | 1.0 (0.5, 3.0) | 3.0 (0.0, 6.0) | 0.0 (0.0, 0.0) | 4.0 (4.0, 4.0) |
| cJADAS10 (parent) | n = 11 | n = 7 | n = 5 | n = 6 | n = 4 | n = 2 | n = 0 | n = 0 |
| 10.0 (2.0, 18.0) | 13.0 (6.5, 18.0) | 9.5 (8.5, 11.0) | 8.0 (3.5, 20.5) | 5.3 (0.8, 10.8) | 12.5 (0.0, 25.0) | – | – | |
| No. of active joints (0–71) | 2.0 (0.0, 6.0) | 10.0 (1.0, 10.0) | 3.5 (1.0, 11.0) | 2.0 (0.0, 11.0) | 0.0 (0.0, 2.0) | 10.0 (0.0, 26.0) | 0.0 (0.0, 0.0) | 11.0 (11.0, 11.0) |
| No. of joints with LOM | 2.0 (0.0, 23.0) | 8.0 (1.0, 12.0) | 2.5 (1.0, 17.0) | 3.0 (0.0, 23.0) | 11.5 (1.0, 19.0) | 2.0 (0.0, 8.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 0.0) |
| Undifferentiated JIA | ||||||||
| n | 33 | 21 | 17 | 21 | 13 | 5 | 4 | 2 |
| PGA (cm) | 1.0 (0.0, 5.5) | 1.5 (0.5, 3.5) | 1.0 (0.0, 5.0) | 0.5 (0.0, 2.0) | 0.5 (0.0, 4.0) | 0.0 (0.0, 1.0) | 0.5 (0.0, 3.0) | 1.3 (0.0, 2.5) |
| cJADAS10 (parent) | n = 29 | n = 17 | n = 11 | n = 12 | n = 8 | n = 3 | n = 0 | n = 0 |
| 7.0 (2.0, 16.0) | 7.5 (4.5, 10.5) | 10.0 (0.5, 15.5) | 4.5 (0.3, 14.8) | 4.8 (1.5, 14.0) | 0.0 (0.0, 7.0) | – | – | |
| No. of active joints (0–71) | 0.0 (0.0, 7.0) | 1.0 (0.0, 2.0) | 0.0 (0.0, 5.0) | 0.0 (0.0, 3.0) | 0.0 (0.0, 3.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 3.5) | 1.0 (1.0, 1.0) |
| No. of joints with LOM | 1.0 (0.0, 7.0) | 1.0 (0.0, 3.0) | 4.0 (1.0, 8.0) | 2.0 (0.0, 5.0) | 1.0 (0.0, 4.0) | 0.0 (0.0, 0.0) | 1.5 (0.0, 6.0) | 1.0 (1.0, 1.0) |
Data are median (Q1, Q3) unless otherwise stated.
cJADAS10: clinical 10-joint Juvenile Arthritis Disease Activity Score; LOM: loss of motion; PGA: Physician Global Assessment of Disease Activity (0–10 VAS); Q1: first quartile; Q3: third quartile; VAS: visual analogue scale.