Table 2.
Longitudinal changes in conventional echocardiographic parameters during breast RT
| Pre-RT (n = 19) |
Post-RT (n = 19) |
6-month F/U (n = 18) | P value* | |
|---|---|---|---|---|
| LVEDD/BSA | 2.6 ± 0.3 | 2.6 ± 0.3 | 2.7 ± 0.2 | .818 |
| LV mass index | 74.7 ± 13.1 | 67.0 ± 15.4 | 68.3 ± 12.3 | .213 |
| LA volume index | 25.3 ± 5.8 | 21.4 ± 6.6 | 22.2 ± 7.3 | .200 |
| LVEF (%) | .493 | |||
| Median (IQR) | 61 (58.5, 65.5) | 62 (59.5, 65) | 63 (61, 65) | |
| Range | 54-69 | 55-72 | 53-68 | |
| Mean ± SD | 61.8 ± 4.4 | 62.2 ± 4.3 | 62.7 ± 3.8 | |
| Global longitudinal strain (%) | –19.3 ± 2.2 | –19.2 ± 1.8 | –19.6 ± 1.8 | .627 |
| A3C | –18.9 ± 2.4 | –19.6 ± 1.8 | –19.7 ± 2.6 | |
| A4C | –19.3 ± 2.5 | –19.2 ± 2.1 | –19.4 ± 2.0 | |
| A2C | –19.7 ± 2.3 | –19.2 ± 2.4 | –19.8 ± 2.0 | |
| Global circumferential strain (%) | –16.6 ± 3.6 | –17.0 ± 2.7 | –16.2 ± 3.5 | .986 |
| Global radial strain (%) | 45.8 ± 23.9 | 44.9 ± 10.4 | 43.3 ± 15.7 | .958 |
| Diastolic parameters | ||||
| Mitral E velocity (cm/s) | 77.3 ± 17.5 | 74.8 ± 15.7 | 77.2 ± 20.4 | .775 |
| Mitral A velocity (cm/s) | 60.5 ± 16.3 | 61.7 ± 11.8 | 62.9 ± 13.8 | .648 |
| Mitral E/A ratio | 1.3 ± 0.4 | 1.3 ± 0.4 | 1.3 ± 0.4 | .417 |
| Septal e’ (cm/s) | 10.3 ± 2.55 | 9.7 ± 3.0 | 10.0 ± 2.9 | .669 |
| Lateral e’ (cm/s) | 13.0 ± 3.2 | 11.7 ± 2.9 | 12.1 ± 3.6 | .323 |
| Septal E/e’ ratio | 7.6 ± 1.9 | 8.0 ± 2.3 | 8.0 ± 1.5 | .274 |
| Lateral E/e’ ratio | 6.2 ± 1.7 | 6.5 ± 1.5 | 6.6 ± 1.2 | .191 |
Abbreviations: A2C = apical 2-chamber; A3C = apical 3-chamber; A4C = apical 4-chamber; BSA = body surface area; IQR = interquartile range; LA = left atrial; LV = left ventricular; LVEDD = left ventricular end diastolic diameter; LVEF = Left ventricular ejection fraction; RT = radiation therapy.
⁎
Wilcoxon signed-rank test between pre-RT and 6-month F/U (N = 17).
Values are mean ± SD.