Fig. 1.

Effect of l-NAME (4 weeks; 7.5 mg/ml in tap water) on heart rate, systolic blood pressure (P syst), diastolic blood pressure (P diast), left ventricular weight (LV), and right ventricula weight (RV). Analysis was performed by tail-cuff in control rats (C, n = 3), l-NAME treated rats (L, n = 6), l-NAME treated rats with SB-3CT (LS, n = 3), and l-NAME treated rats with Tempol (LT, n = 4). Data show means ± SD in black and original data points in red. A) Comparison of heart rates in beats per minute (bpm). Kruskal-Wallis-Test: p = 0.650; B) Comparison of P syst. Kruskal-Wallis Test: p = 0.009; *, p ≤ 0.05 vs. C (exact p-values are 0.020 (L), 0.050 (LS), 0.028 (LT) with Mann-Whitney-U Test). C) Comparison of P diast. Kruskal-Wallis Test: p = 0.005; *, p ≤ 0.05 vs. C (exact p-values are 0.019 (L), 0.046 (LS), 0.032 (LT) with Mann-Whitney-U Test). Organ weights were analyzed in control (C, n = 11); l-NAME (L, n = 13); l-NAME/SB-3CT (LS, n = 8), and l-NAME/Tempol rats (LT, n = 8). D) LV weight normalized to tibia length (LV/TL); One-Way ANOVA (p = 0.002) and Student-Newman-Keuls post hoc test; *, p < 0.05 vs. C; E) RV weight normalized to tibia length (RV/TL); One-Way ANOVA (p = 0.000427) and Student-Newman-Keuls post hoc test; *, p < 0.05 vs. C. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)