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. 2024 Aug 14;10(16):e36120. doi: 10.1016/j.heliyon.2024.e36120

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© 2024 The Authors

This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Fig. 5 — Differentially expressed genes analysis of HO and HO:LiEC. Transcriptome analysis of HO and HO:LiEC (at least n = 2 independent biological replicates). (A) Volcano plot of DEGs comparing HO and HO:LiEC from RNA-seq analysis. Red (HO:LiEC > HO) and blue (HO:LiEC < HO) dots represent DEGs. Up- and down-regulated top 20 DEGs were indicated. (B) The enrichment bubble plot visualizing selected pathways from GO analysis of DEGs (BP; biological process, CC; cellular component, MF; molecular function). The size of each circle represents the number of genes. Red color indicates lower q-value. (C) Heatmap representing up- and down-regulated DEGs in HO:LiEC for selected signaling pathways of GO analysis involved in pro- and anti-inflammatory response, cell migration, extracellular matrix, and receptor signaling pathway.