Table 1.
Overview of the various DPT techniques in the literature showing the missing standardization. All analyzed papers reported about DPTs with iodinated contrast media (CM – contrast medium; DPTs – drug provocation tests; IHR – immediate hypersensitivity reaction; HSR – hypersensitivity reaction; NIHR – non-immediate hypersensitivity reaction; ST – skin test)
| References | Precondition | Intravenous doses with ST-negative CM | Interval between doses | Total CM dose |
|---|---|---|---|---|
| Vernassiere 200420 | Negative ST | 1/100 and 1/10 of dose required for radiol. examination. | 2–24 h | |
| Torres 201210 | Negative ST | 5, 10, 15 ml (1st day) 50, 50 ml (2nd day) |
1 h | 125 ml |
| Salas 20139 | Negative ST | 5, 15, 30, 50 ml | 45 min | 100 ml |
| Lerondeau 201621 | Negative ST | 1/100 and 1/10 of dose required for radiol. examination. | 1 h | |
| Sesé 201622 | Negative ST | 10 ml | 1 dose | 10 ml |
| Morales-Cabeza 201723 | Negative ST | 5, 30, 60 ml (1st day) 120 ml (2nd day) |
30 min | 95 ml120 ml |
| Trautmann 20197 | Negative ST | 0.05, 0.5, 1.0, 5.0, 7.5, 10.0, 25.0 ml (IHR) 1.0, 5.0, 7.5, 10.0, 25.0 ml (NIHR) |
30 min | 49.05 ml48.50 ml |
| Gracia-Bara 201924 | Negative ST | 5, 20 ml (1st day) 50, 50 ml (2nd day the following week) |
1 h | 25 ml100 ml |
| Soria 201925 | – | 20, 30 ml 5, 15, 30 ml (with Grade 3 HSR) |
2 h1.5 h | 50 ml |
| Doña 20205 | Negative ST | 5, 15, 30, 50 ml (IHR) 5, 10, 15 ml (NIHR) 20, 30, 50 ml (NIHR 2nd run 7 days later if no reaction occurred) |
45 min | 100 ml30 ml100 ml |
| Meucci 20206 | Negative ST & characteristics of index reaction | 5, 30, 60 ml (IHR) 5, 30 ml (NIHR) 30, 60 ml (NIHR 2nd run 7–14 days later if no reaction occurred) |
30 min | 95 ml35 ml90 ml |