Fig. 10.

Effects of 6-OHG on NF-κB/NLRP3 signaling pathway in brain tissue of mice with HHBI. (A) Western blotting analysis of NF-κB, p-NF-κB, NLRP3, IκB-α, p-IκB-α, MyD88, IL-6, and TNF-α proteins expression (The original image is provided in the Supplementary Figs. S4 and S5). Quantification analysis of p-NF-κB/NF-κB (B), p-IκB-α/IκB-α (C), NLRP3 (D), MyD88 (E), IL-6 (F), and TNF-α (G). Data (n = 6 per group) are represented as means ± SEM. ^#p < 0.05 and ^##p < 0.01 vs the control group; *p < 0.05 and **p < 0.01 vs the HHBI group. Molecular docking of 6-OHG binding to the NF-κB (H) and NLRP3 (I).