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Effects of 6-OHG on Nrf2/HO-1 signaling pathway in brain tissue of mice with HHBI. (A) Western blotting analysis of Nrf2 and HO-1 proteins expression (The original image is provided in the Supplementary Fig. S3). Quantification analysis of Nrf2 (B) and HO-1 (C). Data (n = 6 per group) are represented as means ± SEM. #p < 0.05 and ##p < 0.01 vs the control group; *p < 0.05 and **p < 0.01 vs the HHBI group. Molecular docking of 6-OHG binding to the Nrf2 (E) and HO-1 (F).
