Figure 4.

Sex-specific dependencies on the MPC for adipose DNL in vivo. (A - B) In vivo incorporation of intraperitoneally administered [U–¹⁴C] glucose into the fatty acyl moieties of total lipids (lipogenesis) in inguinal (A) and epididymal (B) adipose tissue depots and (C–D) mRNA expression of lipogenic genes in epididymal adipose tissue (eWAT) for male and female Mpc1^AD−/− mice or LoxP^+/+ controls fed either a high fat western-style diet (WD, C) or a zero fat, sucrose enriched diet (ZFD, D) for 24 weeks. ∗P < 0.05 for MPC^AD−/− vs LoxP^+/+; ^###P < 0.001 for ZFD vs WD; ^P < 0.05 for female vs male. Data are mean ± SE for 8-10 mice per group.