Figure 7. Impact of smoking on serum levels of several proteins. Differentiation was made in the analysis between non-smokers, ex-smokers and active smokers. All ELISAs were performed in duplicate. Error bars indicate the median ± 95 % confidence interval and significance was determined by Kruskal-Wallis H-test with a p-value of less than 0.05 considered statistically. The serum levels of the MCP-1 (a), Eotaxin 3 (b), CD28 (c), B7-1 (d), B7-2 (e), CTLA-4 (f), MIG (g), IL-1α (h), IL-1β (i), IL-13 (j), PDGF-BB (k), TGFβ2 (l) and TIMP-1 (m) were measured in both the complication and control groups. (n) Receiver operating characteristics (ROC) curve for MIG (AUC = 0.70), (o) Receiver operating characteristics (ROC) curve for CD28 (AUC = 0.53), IL-1α (AUC = 0.64), IL-13(AUC = 0.59) and PDGF-BB (AUC = 0.64).
