Table 3.

Multifactorial logistic regression analysis of serum ALP levels and poor outcomes in patients with ALF following CA

	Unadjusted		Model 1		Model 2
	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
ICU mortality
Per-SD increase of ln (ALP levels)	2.66 (1.53–4.65)	0.001	2.65 (1.52–4.62)	0.001	2.49 (1.31–4.74)	0.005
ALP levels
ALP < 77 IU/L	Ref.		Ref.		Ref.
ALP ≥ 77 IU/L	2.64 (1.48–4.73)	0.001	2.61 (1.45–4.7)	0.001	2.53 (1.24–5.14)	0.010
Hospital mortality
Per-SD increase of ln (ALP levels)	2.62 (1.49–4.62)	0.001	2.59 (1.47–4.56)	0.001	2.21 (1.18–4.16)	0.014
ALP levels
ALP < 77 IU/L	Ref.		Ref.		Ref.
ALP ≥ 77 IU/L	2.72 (1.5–4.92)	0.001	2.69 (1.47–4.9)	0.001	2.29 (1.13–4.64)	0.022
Unfavorable neurologic outcome
Per-SD increase of ln (ALP levels)	2.61 (1.47–4.63)	0.001	2.57 (1.45–4.56)	0.001	2.40 (1.25–4.60)	0.009
ALP levels
ALP < 77 IU/L	Ref.		Ref.		Ref.
ALP ≥ 77 IU/L	2.42 (1.33–4.40)	0.004	2.38 (1.31–4.35)	0.005	2.09 (1.02–4.29)	0.044

ALP, alkaline phosphatase; ALF, acute liver failure; CA, cardiac arrest; CI: confidence interval; OR: odds ratio; ICU: intensive care unit; MAP = mean arterial pressure; CRP, C-reactive protein

Model 1: Adjust for age and sex

Model 2: Adjust for Model1 + adrenaline + cardiac cause + out of hospital + non-shockable rhythm + chronic anticoagulation + shock + vasopressor therapy + CRP + MAP