| Neuron class (% of GPe neurons) | Neuron subclass (% of principal class) | Marker expression; (additional feature) | Validated driver and reporter line(s) | Neurotransmitter(s) |
|---|---|---|---|---|
| PV+ (50%) | aPV+-Kcng4+4,14 | bEtv1, Lhx6, Nkx2.1, Npy2r, Scna4b4,11,14,16,23–28,32–34 | PV-Cre, PV-Flp, PV-tdTomato, cKcng4-Cre14,16,27–29,33,35 | GABA |
| PV+-Lhx6−16,29 | Nkx2.1, Scna4b4,16 | PV-Cre, PV-Flp16 | GABA | |
| Npas1+ (30%) | Npas1+-Foxp2+26 (60%) | Meis2, bPenk, Sox64,25,26,28,38 | Npas1-Cre, cFoxp2-Cre, cFoxp2-Flp14,15,27,28,39 | GABA |
| Npas1+-Nkx2.1+26,28 (40%) | Lhx6, Npr3, Npy2r, Sox64,14,23–28 | Npas1-Cre, cNpr3-Cre, Lhx6-GFP14,28 | GABA | |
| ChAT+ (5%) | N/A | Nkx2.123,25 | ChAT-Cre27,30 | acetylcholine, GABA30 |
| PV−-Npas1− (15%) | N/A | Lhx6; (Sox6−)28 | unknown | unknown |
Footnotes:
a
Kcng4 demarcates a subset of canonical STN-projecting PV+ neurons. However, a marker encompassing all STN-projecting PV+ neurons has yet to be determined.
b
alternative names: Etv1, ER81; Penk.
c
subclass-specific driver.