Table 2.
Correlation between TIGIT expression on T cells and the clinical characteristics of patients TIGIT: T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains
| Variable | Low expression (n = 70) | High expression (n = 70) | P value |
|---|---|---|---|
| Age (≥ 55/<55) | 43/27 | 48/22 | 0.376 |
| Sex (F/M) | 7/63 | 8/62 | 0.784 |
| Etiology | |||
|
Hepatitis B virus Hepatitis C virus Others |
66 0 4 |
65 1 4 |
0.498 |
| AFP level (ng/mL) | |||
|
≤ 400 > 400 |
31 39 |
34 36 |
0.611 |
| ALT (U/L) | |||
|
≤ 40 > 40 |
16 54 |
20 50 |
0.439 |
| AST (U/L) | |||
|
≤ 40 > 40 |
5 65 |
6 64 |
0.753 |
|
VEGF (pg/mL) mean (SD) |
412.86 (184.54) |
451.10 (193.70) |
0.270 |
| Cirrhosis | |||
|
No Yes |
5 65 |
4 66 |
1.000 |
| Child-Pugh class | |||
|
A B |
26 44 |
29 41 |
0.604 |
| ECOG Score | |||
|
0 1 2 |
4 56 10 |
3 47 20 |
0.115 |
| Tumor size (cm) | |||
|
≤ 5 > 5 |
36 34 |
24 46 |
0.040 |
| Tumor number | |||
|
Single Multiple |
14 56 |
11 59 |
0.508 |
| BCLC stage | |||
|
A B C |
6 33 31 |
4 20 46 |
0.039 |
AFP: alpha fetoprotein; ALT: alanine aminotransferase; AST: aspartate aminotransferase; BCLC: Barcelona Clinic Liver Cancer; ECOG: Eastern Cooperative Oncology Group; SD: standard deviation; TIGIT: T-cell immune receptor with immunoglobulin and ITIM domains; VEGF: vascular endothelial growth factor