Table 3.
Correlation between TIGIT expression on T cells and patient immune indicators TIGIT: T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains
| Variable | Low expression (n = 70) | High expression (n = 70) | P value |
|---|---|---|---|
| Total T lymphocytes (%) | 75.15 (11.50) | 71.33 (11.66) | 0.053 |
| Suppressor/cytotoxic cells (%) | 29.50 (10.34) | 26.82 (12.87) | 0.175 |
| Helper/inducible cells (%) | 38.31 (8.56) | 38.85 (9.09) | 0.719 |
| Natural killer cell (%) | 15.44 (9.02) | 16.94 (10.65) | 0.368 |
| B lymphocytes (%) | 8.65 (5.57) | 10.22 (6.18) | 0.118 |
| Helper T cells/Suppressor T cells | 1.56 (1.03) | 1.95 (1.21) | 0.041 |
| Regulatory cells (%) | 10.16 (2.95) | 11.36 (3.30) | 0.025 |
| Proportion of PD-1 + in Mononuclei (%) | 3.87 (7.90) | 4.99 (7.33) | 0.388 |
| Proportion of PD-1 + in CD3 + cells (%) | 4.14 (9.35) | 6.02 (10.04) | 0.254 |
| Proportion of PD-1 + in CD4 + cells (%) | 5.01 (10.35) | 7.29 (11.76) | 0.226 |
| Proportion of PD-1 + in CD8 + cells (%) | 2.91 (8.36) | 5.53 (9.28) | 0.081 |
| Absolute count of total lymphocytes (/uL) | 1481.04 (669.23) | 1428.14 (607.08) | 0.625 |
| Absolute T lymphocyte count (/uL) | 1012.99 (437.57) | 1085.39 (449.49) | 0.336 |
| CD4 + T lymphocyte absolute count (/uL) | 504.31 (282.67) | 518.37 (249.41) | 0.756 |
| CD8 + T lymphocyte absolute count (/uL) | 408.86 (248.79) | 434.09 (249.65) | 0.550 |
| Absolute NK cell count (/uL) | 231.06 (188.13) | 255.47 (198.28) | 0.456 |
| Absolute B cell count (/uL) | 135.76 (121.75) | 122.37 (94.72) | 0.469 |
|
IL-6 (pg/mL) IL-10 (pg/mL) |
85.78 (65.03) 2111.68 (844.17) |
189.15 (144.67) 3236.56 (1166.62) |
0.006 0.001 |
| PD-1 (pg/mL) | 345.6 (134.84) | 480.72 (269.98) | 0.052 |
| CD155 (ng/mL) | 115.78 (57.46) | 119.82 (42.07) | 0.636 |
| IFN-γ(pg/mL) | 2759.78 (1471.40) | 1476.34 (995.34) | 0.003 |
IFN-γ: interferon gamma; IL: interleukin; PD-1: programmed cell death protein 1; TIGIT: T-cell immune receptor with immunoglobulin and ITIM domains