Table 3.

Choice of design parameters for the Fill-it-up-design

Parameter		Value
$n_H$	Sample size of historical control group H	500
$\delta$	Effect size	0.275
$1-{\beta }_{S_1}=1-{\beta }_{S_2}$	Power of ($S_1$) and ($S_2$)	0.8
${\alpha }_{S_1}={\alpha }_{S_2}$	Significance Level of ($S_1$) and ($S_2$)	0.05
${\alpha }_{\mathit{Ept}}$	Significance Level of (Ept)	$\{0.01,0.05,0.1,0.2\}$
$\mathrm{\Delta }$	Equivalence Margin	$\left[\sqrt{\frac{1}{n_H}+\frac{1}{n_C}},·,z_{1-{\alpha }_{\mathit{Ept}}},,,\delta \right)$