Table 1. FBPase inhibitory potency and specificity.
Enzyme | MB05032 EC50, nM |
---|---|
Human liver FBPase | 16 ± 1.5 |
Human muscle FBPase | 29 ± 1 |
Rat liver FBPase | 61 ± 14 |
Human erythrocyte AMP deaminase | >100,000 |
Rabbit muscle glycogen phosphorylase | >100,000 |
Human AMP-activated protein kinase | >100,000 |
Rabbit muscle adenylate kinase | >500,000 |
Rabbit liver phosphofructokinase | >100,000 |
EC50 values were determined as described in Materials and Methods.