Table 2.
Univariate/Multivariate Cox Regression Analysis of NFS1 Expression, OS, and Clinicopathological Characteristics in Patients with GC
| Characteristics | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| Hazard Ratio (95% CI) | P value | Hazard Ratio (95% CI) | P value | |
| Gender | ||||
| Male vs Female | 0.988 (0.665–1.468) | 0.952 | 0.967 (0.631–1.482) | 0.878 |
| Age (years) | ||||
| ≥65 vs <65 | 1.428 (1.009–2.020) | 0.044 | 1.133 (0.786–1.633) | 0.502 |
| Tumor location | ||||
| Upper vs Middle + lower | 1.063 (0.743–1.521) | 0.739 | 0.854 (0.583–1.251) | 0.418 |
| Tumor size (cm) | ||||
| ≥5 vs <5 | 2.220 (1.584–3.112) | <0.001 | 1.221 (0.850–1.755) | 0.280 |
| Depth of invasion | ||||
| T3 + T4 vs T1 + T2 | 8.559 (3.766–19.450) | <0.001 | 2.248 (0.861–5.868) | 0.098 |
| Lymph node metastasis | ||||
| Present vs Absent | 7.891 (4.819–12.921) | <0.001 | 2.776 (1.060–7.274) | 0.038 |
| M stage | ||||
| M1 vs M0 | 7.811 (4.857–12.561) | <0.001 | 4.169 (2.529–6.872) | <0.001 |
| Differentiation | ||||
| Poor + undifferentiated vs Well + moderate | 2.035 (1.413–2.929) | <0.001 | 1.559 (1.049–2.316) | 0.028 |
| TNM stage | ||||
| III + IV vs I + II | 8.024 (4.988–12.906) | <0.001 | 1.662 (0.624–4.424) | 0.309 |
| NFS1 | ||||
| High vs Low | 3.362 (2.138–5.287) | <0.001 | 2.516 (1.571–4.031) | <0.001 |