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. 2024 Sep 5;19:9071–9090. doi: 10.2147/IJN.S472882

Figure 9.

Figure 9

Ex vivo TEM images of positive control group: (a) elongated mitochondria; (b) cytoplasmic vacuolization and expanded ER; (c) extended cytoplasmic vacuolization and autophagosomes; (d) autophagosomes, melanosomes, vacuoles, elongated mitochondria, secondary lysosomes; (e) autophagosomes, melanosomes, vacuoles; (f) debris of a necrotic melanoma cell mixed with blood cells outside capillaries.

Note: * – NIR-797–loaded PLGA NPs.

Abbreviations: n, nucleus; nu, nucleolus; er, endoplasmic reticulum; me, melanosomes; rbc, red blood cell; mc, melanoma cell; mi, mitochondria; v, vacuoles; ap, autophagosome; sl, secondary lysosomes.