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. 2024 Jun 10;9(11):e168825. doi: 10.1172/jci.insight.168825

Figure 3. Glucose uptake and lactate secretion in isolated kidney sections.

Figure 3

(A and B) Kidney sections (n = 16) from 10- to 12-week-old male C57BL/6J mice have an SGLT2-dependent increase in glucose uptake (A) from normal (NG) to high glucose (HG) and lactate production (B). The SGLT2 inhibitor empagliflozin (EMPA) has a dose-dependent effect to reduce glucose uptake and lactate secretion. P values for A and B were calculated using 1-way ANOVA and Tukey’s test for multiple comparison testing. (C) Lactate secretion is significantly correlated with glucose uptake, assessed using the Pearson’s correlation coefficient. (D) Urine lactate is reduced in SGLT2-KO (SGLT2–/–) mice via t test (7-month-old male mice, n = 6 both groups) compared with WT by 2-tailed Welch’s t test. Data represent mean ± SD.