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. 2024 May 7;9(11):e165869. doi: 10.1172/jci.insight.165869

Figure 4. Long-term microdystrophin expression causes cardiomyopathy in D2.mdx mice.

Figure 4

Male D2.mdx mice were treated with microdystrophin (μDys) gene therapy at 1 month of age (refer to Figure 2A). (A and B) End diastolic volume (A) and ejection fraction (B) were measured in D2.WT, untreated D2.mdx, and μDys-treated D2.mdx mice at 6, 12, and 18 months of age. (C) Representative PSR-stained images of the heart with accompanying fibrosis quantifications for these groups. Scale bar: 75μm. Data were analyzed using 1-way ANOVA with Tukey HSD post hoc tests (α = 0.05) and displayed as box-and-whisker plots (A–C) (boxes indicate second and third quartiles, and error bars represent the minimum and maximum values). *P < 0.05 versus D2.WT values; #P < 0.05 versus D2.mdx values; %P < 0.05 versus MDC1 values; $P < 0.05 versus MDC2 values; &P < 0.05 versus MDC3 values.