Skip to main content
. 2024 Jun 17;9(14):e174168. doi: 10.1172/jci.insight.174168

Figure 1. CM9-specific CD8+ T cells contribute to natural control of viremia during chronic infection with SIV.

Figure 1

(A) Schematic representation of the experiment. Immunotoxin was administered to 5 Mamu-A*01+ rhesus macaques chronically infected with SIVmac239. (B) Representative flow cytometry plots showing CM9 tetramer staining versus CD8. Plots are gated on live memory CD8+ events. (C) CM9-specific CD8+ T cell frequencies among PBMCs (parent = CD8+ T cells). (D) CM9-specific CD8+ T cell frequencies in BAL, jejunum, and LNs (parent = CD8+ T cells). (E) Plasma viral loads. (F) Extended quantification of CM9-specific CD8+ T cell frequencies among PBMCs (parent = CD8+ T cells). Each symbol represents 1 macaque (C–F). Significance was determined using a 2-tailed paired t test (C and D). *P < 0.05. DPI, days postimmunotoxin.