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. 2024 Jun 17;9(14):e174168. doi: 10.1172/jci.insight.174168

Figure 2. Immunotoxin administration does not alter viral load kinetics during acute infection with SIV.

Figure 2

(A) Schematic representation of the experiment. Immunotoxin was administered to 5 Mamu-A*01+ rhesus macaques acutely infected with SIVmac239. Immunotoxin was withheld from 5 control Mamu-A*01+ rhesus macaques treated otherwise identically. (B) CM9-specific CD8+ T cell frequencies among PBMCs (fold change). (C) Total memory CD8+ T cell frequencies among PBMCs (parent = memory T cells). (D) Total memory CD4+ T cell frequencies among PBMCs (parent = memory T cells). (E) Plasma viral loads. (F) CD4+ T cell–associated viral loads. Each symbol represents 1 macaque (B–F). Shaded areas depict mean values (B–E). Horizontal bars indicate median values (F). Significance was determined using AUC analysis (B–E) or a mixed-effects ANOVA with Šídák correction (F). DPI, days postinfection.