Figure 2. Lineage Resolved Simulations for Comparing Simulated and Experimental Cell Viability Assays.

A-C. Dose response simulations for an example drug (trametinib). Median (across simulation replicates) cell population dynamics for several doses (A) and cell population lineage dendrograms for specific doses: 0 μM (B) and 0.1 μM (C) are shown. D-G. Simulated dose responses measured in GR-value for four drugs compared experimental data. Error bars are standard error taken from original experimental data, or as calculated across simulation replicates (n=10).