Fig. 7. Transcriptional determinants of axon guidance molecules for individual receptor types.

A. Correlation heatmap between receptor types calculated from co-expressed AG and TF genes. Receptor types are color-coded. B. 3-D heatmap showing the Jaccard Indices between AG and TF genes for each of the VRs in the dataset. C-G. Heatmaps showing Jaccard Indices of TF-AG associations for V1R (C and D) and V2R types (E-G). The lists of TF and AG genes here are abridged from the full list to enhance visualization. (C), these receptors share Meis2 expression but different AG genes. Note that Vmn1r185 and vmn1r69 both recognize female identify pheromones. (D), similarity and distinction of AG/TF expression for three V1R types that are located in the same genomic location and with high sequence homology. (E and F), shared TFs and AG genes for broadly (E) and uniquely (F) expressed V2R types. (G), distinct TFs and AGGs for uniquely expressed V2R types.