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. 2024 Jul 22;9(14):e181042. doi: 10.1172/jci.insight.181042

Figure 1. Baroreflex testing in sham and infarcted male mice.

Figure 1

(A) Myocardial infarction was created by ligation of the LAD coronary artery. (B) Two to 3 weeks after MI, the presence of cardiac fibrosis was confirmed in infarcted males. Scale bar: 500 μm. (C and D) Examples of blood pressure and heart rate tracings after infusion of phenylephrine in male sham and MI mice. (E and F) BRS was measured as the slope of the beat-to-beat RR interval with respect to the systolic blood pressure. Representative slopes of BRS in a sham and an infarcted male mouse in response to phenylephrine infusion are shown. (G) BRS was significantly reduced in male infarcted mice (n = 6) versus sham (n = 7) mice (P < 0.001). (H) The ratio of ΔRR/ΔBP was also reduced in male MI versus male sham mice in response to phenylephrine, indicative of vagal dysfunction (P < 0.001). Data are shown as mean ± SEM. **P < 0.01; unpaired Student’s t test was used for intergroup comparisons.