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. 2024 Jun 24;9(12):e174153. doi: 10.1172/jci.insight.174153

Figure 2. Fold-changes of concentration of cfmiRNAs in extracted RNA from plasma over concentration of cfmiRNAs in whole plasma, according to different platforms used.

Figure 2

(A) RNA extracted from plasma over concentration of miRNAs in whole plasma measured by EdgeSeq, (B) miRNAs in RNA extracted from plasma measured by RNA-Seq (SeqMatic) over concentration of cfmiRNAs in whole plasma measured by EdgeSeq, and (C) cfmiRNAs in RNA extracted from plasma measured by RNA-Seq (LC Sciences) over concentration of cfmiRNAs in whole plasma measured by EdgeSeq analyzed using the voom, lmFit, and eBayes functions in the limma package. FC, fold-change. (D) Spearman correlation coefficients between concentration of cfmiRNAs in RNA extracted from plasma measured by qRT-PCR and concentration of miRNAs in whole plasma measured by EdgeSeq. Red dots indicate risk ESKD-associated cfmiRNAs. Blue dots indicate protective ESKD-associated miRNAs. Detailed comparisons are shown in Table 3.