Figure 4.

Mrc1 cooperates with Mcm2 in recycling of parental histones to the lagging strand

(A) Workflow of xSCAR-seq in fission yeast.

(B) Partition of H3K36me3 (top) and H4K20me0 (bottom) at a genomic region. Replication origin centers are depicted as black lines with their respective firing efficiency score.

(C) Average partitioning score across replication initiation centers (with score >20) for parental (H3K36me3, top) and newly synthesized (H4K20me0, bottom) histones.

(D) Heatmap representing the partitioning score across all replication origin centers (score >20) for H3K36me3 (left) and H4K20me0 (right). Each row represents the partition score of xSCAR-seq sequence reads at one origin. Average of two independent replicates.

See also Figure S4.