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. 2024 Sep 5;187(18):5029–5047.e21. doi: 10.1016/j.cell.2024.07.017

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© 2024 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Mrc1 coordinates parental histone inheritance within the replisome for heterochromatin maintenance

(A) Overview of the Mrc1-HBD (710–800; based on Figure 5B) and the HBS (782–879) domains. Colored residues were mutated in this study.

(B) Cells expressing mCherry (n = 6). WT, mrc1ΔHBS, and mrc1-KAF values are included for comparison from Figure 2B. Data are represented as mean ± SD.

(C and E) Average partitioning score across replication initiation centers (with score >20) for parental (H3K36me3) histones (C) and newly synthesized (H4K20me0) histones (E).

(D and F) Heatmap representing the partitioning score across all replication origin centers (score >20) for H3K36me3 (D) and H4K20me0 (F).

See also Figure S7.